b'Zimeta dipyrone) with additional ingredients addedSTEP BY STEP(dipyrone injection) to maintain masking during administration. 500mg/mL injectionTable 1: Adverse Reactions Reported For intravenous use in horsesDuring the Field Study with ZimetaNon-steroidal anti-inflammatory drug (NSAID) Zimeta TM Control CAUTION: Federal law (U.S.A.) restricts this(dipyroneProduct drug to use by or on the order of a licensedAdverse Reaction injection) (N=31) example, by different drying times afterwhen the remodeling process cant keep veterinarian.(N=107) rainfall, especially if parts of a surface areup with the rate of damage.Before using this product, pleaseElevated Serum5 (5%) 5 (16%) shadedcan cause areas to have incon- Roepstorff says one of his favorite consult the product insert, aSorbitol Dehydro-summary of which follows: genase (SDH) sistent firmness or grip, Peterson says.surface-related training methods is road Indication: Zimeta (dipyrone injection) isHypoalbuminemia 3 (3%) 1 (3%) work on tarmac or hard gravel, by work-indicated for the control of pyrexia in horses.Gastric Ulcers 2 (2%) 0 (0%)DosageandAdministration:AlwaysHyperemic Mucosa1 (1%) 0 (0%) Maintenance Musts ing up gradually in intensity and amount. provide the Client Information Sheet withRight Dorsal Colon The solution to moisture and incon- Its a very good example of understanding theprescription.AdministerZimetabyProlonged1 (1%) 0 (0%)intravenous injection, once or twice daily,Activated Partialsistency is fairly simple: Maintain thethat there are no poor surfaces, only poor at 12 hour intervals, for up to three days,Thromboplastinsurface. Harrowing and rolling can makeuse of surfaces.at a dosage of 30 mg/kg (13.6 mg/lb). SeeTime (APTT)product insert for complete dosingElevated Creatinine 1 (1%) 0 (0%) a huge difference in both water content and administration information. Injection Site1 (1%) 0 (0%) and consistency, Peterson says. RollingKnow Your Horse and Your SurfaceContraindications:HorseswithReaction hypersensitivitytodipyroneshouldnotAnorexia 1 (1%) 1 (3%) can block out incoming rain, and har- If there is an ideal surface, says receive Zimeta. Due to the prolongation of prothrombin time (PT) and associated clinicalSee Product Insert for completerowing can open the surface to help it dryRoepstorff, its a very broad category of signs of coagulopathy, dipyrone should not beAdverse Reaction information. out evenly. Maintenance makes a hugesurfaces due to the many factors at play. given more frequently than every 12 hours. Information for Owners or Person Warnings: For use in horses only. Do not useTreating Horse: A Client Information Sheetdifference in injury risk, he adds. One of the main factors is your horse, in horses intended for human consumption.should be provided to the person treatingIn her study on sand-fiber mix footing,he says. Depending on his conformation, Do not use in any food producing animals,thehorse.Treatmentadministratorsand including lactating dairy animals. caretakers should be aware of the potentialCrevier-Denoix found that rolling createddiscipline, genetics, prior health issues, for adverse reactions and the clinical signs Human Warnings: Care should be takenassociated with NSAID intolerance. Adverselanding forces and angles that put jump- and personal preferences, your horse will to ensure that dipyrone is not accidentally injected into humans as studies have indicatedreactions may include colic, diarrhea, anding horses at greater risk of injury com- probably work better and have less risk of thatdipyronecancauseagranulocytosis decreased appetite. Serious adverse reactions can occur without warning and, in somepared to harrowing, she says. But even ainjury on certain surfaces than others. in humans. situations, result in death. Clients should beharrowed arena can lose its benefits if itTo determine what that surface is, Not for use in humans. Keep this and all drugsadvised to discontinue NSAID therapy and out of reach of children. In case of accidentalcontact their veterinarian immediately if anygets compacted from frequent use. know your horse and surfaces in general. exposure, contact a physician immediately.signs of intolerance are observed.DirectcontactwiththeskinshouldbeThis compacting caused by treadingRead up on the properties, biomechan-avoided. If contact occurs, the skin should beEffectiveness:Theeffectivenessphase wasarandomized,masked,controlled,hooves doesnt just happen when trainingics, and characteristics of the different washed immediately with soap and water.multicenter, field study conducted to evaluate As with all injectable drugs causing profoundtheeffectivenessofZimeta(dipyroneat home, it happens in competition, too.kinds of surfaces, Roepstorff says. Get physiologicaleffects,routineprecautionsinjection) administered intravenously at 30 should be employed by practitioners whenThink about show jumping, Petersonfamiliar with terminology and textures, handling and using loaded syringes to preventmg/kg bodyweight in horses over one year of age with naturally occurring fevers. Enrolledsays. These horses follow the same pathand know how these surfaces feel.accidental self-injection. horses had a rectal temperature 102.0F. Precautions:HorsesshouldundergoaA horse was considered a treatment successand compact that surface with each strideThat doesnt mean going out and thorough history and physical examinationif 6 hours following a single dose of studyand jump. Theres going to be a competi- stomping around the arenaalthough before initiation of any NSAID therapy. drug administration the rectal temperature decreased2.0Ffromhour0,orthetive advantage for earlier horses, but thereyou could, says Roepstorff. The best way As a class, NSAIDs may be associated withtemperature decreased to normal (101.0F).platelet dysfunction and coagulopathy. Zimetaare also going to be more animal welfareis tolisten to your horse, he says. Do has been shown to cause prolongation ofOne hundred and thirty-eight horses received coagulation parameters in horses.Therefore,treatment(104Zimetaand34controland soundness issues for the later horsesyou feel him changing his gait or his will-horsesonZimetashouldbemonitored product) and 137 horses (103 Zimeta andhitting that more compacted footing.ingness to move? Consider how he acts on forclinicalsignsofcoagulopathy.34 control product) were included in the Caution should be used in horses at risk statisticalanalysisforeffectiveness.At6different surfaces, and keep in mind that for hemorrhage. hours post-treatment, the success rate was 74.8% (77/103) of Zimeta treated horses andConsistent, With Variation this could always relate back to injury or As a class, NSAIDs may be associated with20.6% (7/34) of control horses. The results gastrointestinal, renal, and hepatic toxicity.You want your footing consistentsoreness. If you notice different behavior Sensitivity to drug-associated adverse eventsof the field study demonstrate that Zimeta varies with the individual patient. Consideradministered at 30 mg/kg intravenously wasacross a training surface, but for op- on a new surface, give him time to adapt.effective for the control of pyrexia 6 hours stopping therapy if adverse reactions, suchfollowing treatment administration.timum orthopedic health you want toRoepstorffs team developed a thor-asprolongedinappetenceorabnormal feces, could be attributed to gastrointestinalRefer to the Product Insert forswitch up the surfaces on which youough, easy-to-follow, science-based foot-toxicity. Patients at greatest risk for adversecomplete Effectiveness information.train. Horses can adapt to these surfaces,ing guide that riders can download from events are those that are dehydrated, onStorage Information: Store at Controlled diuretictherapy,orthosewithexistingRoom Temperature 20 and 25C (68 andprovided they have the chance to do sothe FEI at bit.ly/3doVXIt. Its a great way renal,cardiovascular,and/orhepatic77F); with excursions permitted between 15 dysfunction.Concurrentadministrationofgradually, our sources say. to understand how complex the horse-potentiallynephrotoxicdrugsshouldbeand 30C (59 and 86F). Protect from light.Multi-dosevial.Usewithin30daysof Its important to habituate horses tofooting dynamic is and how it can affect carefullyapproachedoravoided.Sincefirst puncture.manyNSAIDspossessthepotentialtodifferent surfaces, from very soft to rela- the biomechanicsand, therefore, the produce gastrointestinal ulcerations and/orHow Supplied: Zimeta is available gastrointestinal perforation, concomitant useas a 500mg/mL solution in a 100mL,tively firm, so that his bones and musclesoundnessof the horse, he says. of Zimeta with other anti-inflammatory drugs,multi-dose vial. coordination can adapt and the stresses such as NSAIDs or corticosteroids, should beApproved by FDA under NADA # avoided. The influence of concomitant drugs141-513 NDC 86078-245-01 on tendon are better adjusted by theTake-Home Messagethat may inhibit the metabolism of Zimeta has not been evaluated. Drug compatibilityManufactured for: nervous system, says Denoix.The footing beneath your horses feet should be monitored in patients requiringKindred Biosciences, Inc. A gradual buildupstarting with slowaffects his overall soundness. As studies adjunctive therapy.1555 Bayshore Hwy, Suite 200,Burlingame, CA 94010gaits for 10 to 15 minutes at a timeonon surfaces continue, were finding that The safe use of Zimeta in horses less thanTo report adverse reactions call three years of age, horses used for breeding,new surfaces allow the horses musculo- the horse/ground dynamic is extremely or in pregnant or lactating mares has not beenKindred Biosciences, Inc. atevaluated.Considerappropriatewashout1-888-608-2542. skeletal system to adjust, Roepstorff says.complex, and there is no perfect surface times when switching from one NSAID toZimeta is a trademark ofKindredThe body adapts by sustaining micro- for all situations. Likewise, as long as its another NSAID or a corticosteroid. Biosciences, Inc.AdverseReactions:Adversereactions 2019 Kindred Biosciences, Inc. All rightsscopic damage to bonein particular,well-maintained and consistent, theres reported in a controlled field study of 138reserved. subchondral bone, which lies beneath andno terrible one for all situations, either. horses of various breeds, ranging in ageRev. 11-2019from 1 to 32 years of age, treated withsupports joint surface cartilageand thenThe best riders can do today is know their Zimeta (n=107) or control product (n=31)KB50002_ZIV-BS-1remodeling. But taking it slowly is critical.horses and their surfaces and make sound are summarized in Table 1. The control product was a vehicle control (solution minusFatigue fractures and other lesions occurdecisions about riding on them.h36May 2020The Horse|TheHorse.com'