b'Theres nothing else like it.Over the past 30 years, Adequan i.m. (polysulfated glycosaminoglycan) has been recommended millions of times 1to treat degenerative disease, and with good reason. From day one, its been the only FDA-Approved equine PSGAG joint precription available, and the only one proven to.2, 3Restore synovial joint lubricationRepair joint cartilageReverse the disease cycleReduce in ammationWhen you start with it early and stay with it as needed, horses may enjoy greater mobility over a lifetime. Discover if Adequan is the right choice. Talk to your American Regent 2, 4, 5Animal Health sales representative or call (800) 458-0163 to order.BRIEF SUMMARY: Prior to use please consult the product insert, a summary of which follows: CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. INDICATIONS: Adequani.m. is recommended for the intramuscular treatment of non-infectious degenerative and/or traumatic joint dysfunction and associated lameness of the carpal and hock joints in horses. CONTRAINDICATIONS: There are no known contraindications to the use of intramuscular Polysulfated Glycosaminoglycan. WARNINGS: Do not use in horses intended for human consumption. Not for use in humans. Keep this and all medications out of the reach of children. PRECAUTIONS: The safe use of Adequan i.m. in horses used for breeding purposes, during pregnancy, or in lactating mares has not been evaluated. For customer care, or to obtain product information, visit www.adequan.com. To report an adverse event please contact American Regent, Inc. at (800) 734-9236 or email [email protected]. Please see Full Prescribing Information atwww.adequan.com.1Data onle. 2Adequan i.m. Package Insert, Rev 1/19. 3Burba DJ, Collier MA, DeBault LE, Hanson-Painton O, Thompson HC, Holder CL: In vivo kinetic study on uptake and distribution of intramuscular tritium-labeled polysulfated glycosaminoglycan in equine bodyuid compartments and articular cartilage in an osteochondral defect model. J Equine Vet Sci 1993; 13: 696-703.4Kim DY, Taylor HW, Moore RM, Paulsen DB, Cho DY. Articular chondrocyte apoptosis in equine osteoarthritis. The Veterinary Journal 2003; 166: 52-57. 5McIlwraith CW, Frisbie DD, Kawcak CE, van Weeren PR. Joint Disease in the Horse.St. Louis, MO: Elsevier, 2016; 33-48.Adequan and the Horse Head design are registered trademarks of American Regent, Inc. 2019, American Regent, Inc. PP-AI-US-0222 2/20195544 Adequan 2019 Trade Ad The Horse AAEP.indd 1 10/29/19 9:27 AMAmericanRegent_pg.indd 1 10/8/19 8:44 AM'