b'WHATS PLAGUING YOUR PROBLEM MARE?EQUIDONEGel(domperidone)For oral use in horses only.BRIEF SUMMARY (For full prescribing information, see package insert.) CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.DESCRIPTION: Domperidone is a D2 CDC/DR. RODNEY M. DONLAN; JANICE CARRdopamine receptor antagonist. The chemical formula is 6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl) propyl]piperi-din-4-yl]-1H-benzimidazol-2-one.INDICATION: For prevention of fescue toxicosis in periparturient mares.Contraindication: Horses with hypersen-sitivity to domperidone should not receive EQUIDONE Gel.WARNINGS: Failure of passive transfer ofThe sticky substance woven between bacteria in this scanning electron microscope image is a biofilm.immunoglobulins (IgG) may occur when using EQUIDONE Gel even in the absence of leakage of colostrum or milk. All foalsOther Causes of Infertility resumption of fertility in mares with a his-born to mares treated with EQUIDONE GelAdditional problems you might en- tory of unexplained infertility, he says.should be tested for serum IgG concen- counter in certain mares include: Uterine cysts Endometrial cysts occur trations. Do not use in horses intended for human consumption. Genetic abnormalities of the embryomainly in middle-aged to older mares and If a mare gets pregnant and loses it byare unusual in young mares, says Mc-HUMAN WARNINGS: Not for use in humans. For oral use in animals only.30 days, sometimes there are chromo- Cue. Uterine cysts visible on ultrasound Keep this and all drugs out of the reachsomal or allele translocations (essentially,usually indicate scar tissue or fibrosis of children. Pregnant and lactating women should use caution when handlinggenetic flaws with that embryo) that maywithin the uterine lining. If a mare has EQUIDONE Gel, as systemic exposurecause this to happen, Wolfsdorf says.just a few small cysts, they generally to domperidone may affect reproductive hormones. Consult a physician in case ofCervical tears Mares that suffer cervi- dont interfere with her ability to get or accidental human exposure. cal tears during foaling generally have astay pregnant, but if cysts are large or history of chronic endometritis, she says.numerous, they could be problematic. PRECAUTIONS: EQUIDONE Gel may lead to premature birth, low birth weightThe damaged cervix will not provide aThis is because when the embryo comes foals or foal morbidity if administered >15good seal until you repair it, and the maredown through the oviduct and enters the days prior to the expected foaling date. Accurate breeding date(s) and an expectedwill continue to develop endometritis. uterus, it must be able to move around foaling date areOnce you repair a cervix, however,before it fixes in the base of a horn (the needed for the safe use of EQUIDONE Gel.Do not use in horses with suspected orit may not be able to relax properly,mare has two uterine horns extending confirmed gastrointestinal blockage, asWolfsdorf adds. This can cause the marefrom the uterine body). This movementdomperidone is a prokinetic drug (it stimu- to retain fluid post-breeding. She mustof the embryo is important in signaling to lates gut motility).also be monitored when she foals, be- the mare she is pregnant.ADVERSE REACTIONS: The mostcause she may tear it again; it may needIf a cyst blocks the embryos ability to common adverse reactions associated with treatment with EQUIDONE Gel areto be repaired after each foaling. move, the mare will not recognize she is premature lactation (dripping of milk priorBlocked oviduct Veterinarians typicallypregnant and will return to heat, says to foaling) and failure of passive transfer. dont think about oviducts as causing fer- Wolfsdorf. If the embryo attaches next to tility issues until theyve ruled everythinga large cyst or numerous cysts, it cannot else out. Mares with blocked oviductsget the appropriate amount of nutrients generally have a specific history, says(from the uterine wall). Wolfsdorf. They may be in their mid- toVeterinarians can remove small cysts older years, with good reproductive con- with a laser during hysteroscopic exams. formation, no evidence of endometritis,They use snares or other devices to manu-Distributed by:Dechra Veterinary Products and have been bred to fertile stallions butally remove larger cysts. 7015 College Boulevard, Suite 525Overland Park, KS 66211, 866-933-2472 havent produced a pregnancy. 2016 Dechra Ltd. While oviduct blockages can be difficultTake-Home MessageEQUIDONE is a registered trademarkto diagnose, researchers have recently de- Resolving a breeding problem involves of Dechra Ltd. All rights reserved.NADA 141-314, scribed several treatment options, includ- knowing the mares reproductive history, Approved by FDAing cannulation and lavage of the oviductsperforming a thorough reproductive ex-and topical application of prostaglandinamination, and pursuing further diagnos-E1 or E2 to dilate them and relieve thetic procedures (such as biopsies, cultures, blockage, says McCue. Administration ofetc.) if needed. Based on a good diagno-the prostaglandin E1 misoprostol in onesis, our sources say most problems can be study, for instance, showed a remarkableresolved with appropriate treatment.h24January 2020The Horse|TheHorse.comEquidone_legal_insert_vertical_TheHorse.indd 1 10/25/16 11:26 AMProblemMares USE.indd 24 12/3/19 3:34 PM'