b'Zimeta dipyrone) with additional ingredients added 2019 AAEP CONVENTION WRAP-UP(dipyrone injection) to maintain masking during administration. 500mg/mL injectionTable 1: Adverse Reactions Reported For intravenous use in horsesDuring the Field Study with ZimetaNon-steroidal anti-inflammatory drug (NSAID) Zimeta TM Control CAUTION: Federal law (U.S.A.) restricts this(dipyroneProduct drug to use by or on the order of a licensedAdverse Reaction injection) (N=31) that 67.7% of OPUs yielded at least oneNow, he said, his program sees 76% veterinarian.(N=107) transferrable embryo. pregnancy rates after transfer of ICSI Before using this product, pleaseElevated Serum5 (5%) 5 (16%) To evaluate the influence of the donorembryos and a greater than 55% chance consult the product insert, aSorbitol Dehydro-summary of which follows: genase (SDH) mare and stallion on results, he thenof getting a live foal. Twins and triplets Indication: Zimeta (dipyrone injection) isHypoalbuminemia 3 (3%) 1 (3%) narrowed the stallion pool down to the 16are an uncommon (approximately 1%) indicated for the control of pyrexia in horses.Gastric Ulcers 2 (2%) 0 (0%)DosageandAdministration:AlwaysHyperemic Mucosa1 (1%) 0 (0%) used for at least four different mares andbut frustrating cause of foal loss.provide the Client Information Sheet withRight Dorsal Colon the mare pool to the 26 undergoing atStouts take-home messages to the theprescription.AdministerZimetabyProlonged1 (1%) 0 (0%)intravenous injection, once or twice daily,Activated Partialleast four OPUs. audience included:at 12 hour intervals, for up to three days,ThromboplastinIt became apparent that while there With a good commercial embryo at a dosage of 30 mg/kg (13.6 mg/lb). SeeTime (APTT)product insert for complete dosingElevated Creatinine 1 (1%) 0 (0%) was a stallion effect on parameters ofproduction system you can be very suc-and administration information. Injection Site1 (1%) 0 (0%) ICSI success, there was a more markedcessful, with upward of 75% pregnancy Contraindications:HorseswithReaction hypersensitivitytodipyroneshouldnotAnorexia 1 (1%) 1 (3%) mare effect, said Stout.rates and 55% live foal rates.receive Zimeta. Due to the prolongation of prothrombin time (PT) and associated clinicalSee Product Insert for completeThe percentage of blastocysts producedSome mares are better donors than signs of coagulopathy, dipyrone should not beAdverse Reaction information. per injected oocyte was 16-27% for stal- others.given more frequently than every 12 hours. Information for Owners or Person Warnings: For use in horses only. Do not useTreating Horse: A Client Information Sheetlions compared to 5-45% for mares. Its important for owners to know that in horses intended for human consumption.should be provided to the person treatingThe first OPU is predictive, saidthe first OPU is predictive of a mares Do not use in any food producing animals,thehorse.Treatmentadministratorsand including lactating dairy animals. caretakers should be aware of the potentialStout. If the first OPU-ICSI attempt infuture chances of success.Human Warnings: Care should be takenfor adverse reactions and the clinical signsa mare is successful, in 77% of cases theIf the first OPU isnt successful, chang-to ensure that dipyrone is not accidentallyassociated with NSAID intolerance. Adverse injected into humans as studies have indicatedreactions may include colic, diarrhea, andsecond will be successful as well, anding the stallion might help.thatdipyronecancauseagranulocytosis decreased appetite. Serious adverse reactions can occur without warning and, in somevice versa. If it doesnt yield success theAlexandra Beckstettin humans. situations, result in death. Clients should befirst time, expect to be disappointed the Not for use in humans. Keep this and all drugsadvised to discontinue NSAID therapy and out of reach of children. In case of accidentalcontact their veterinarian immediately if anysecond time, too, especially if you use theSAFETY IN RACINGexposure, contact a physician immediately.signs of intolerance are observed.Directcontactwiththeskinshouldbesame stallion. Using Stride Parameters to Prevent avoided. If contact occurs, the skin should beEffectiveness:Theeffectivenessphase wasarandomized,masked,controlled,While the overall stallion effect appearsRacing Injuries washed immediately with soap and water.multicenter, field study conducted to evaluate As with all injectable drugs causing profoundtheeffectivenessofZimeta(dipyroneto be moderate, Stout said it can be worthAs the horse racing industry continues physiologicaleffects,routineprecautionsinjection) administered intravenously at 30 should be employed by practitioners whentrying a different stallion if the mareto search for ways to prevent catastrophic handling and using loaded syringes to preventmg/kg bodyweight in horses over one year of age with naturally occurring fevers. Enrolledfailed to produce an embryo the first time. injuries, researchers are evaluating a accidental self-injection. horses had a rectal temperature 102.0F.Mare age does have some effect on out- variety of potentially predictive fac-Precautions:HorsesshouldundergoaA horse was considered a treatment success thorough history and physical examinationif 6 hours following a single dose of studycome but only in as much as older marestors. One of those is a racehorses stride before initiation of any NSAID therapy. drug administration the rectal temperature decreased2.0Ffromhour0,orthehave fewer follicles and, therefore, yieldcharacteristics. As a class, NSAIDs may be associated withtemperature decreased to normal (101.0F).platelet dysfunction and coagulopathy. Zimetafewer oocytes. Surprisingly, said Stout,Chris Whitton, BVSc, FANZCVS, PhD, has been shown to cause prolongation ofOne hundred and thirty-eight horses received coagulation parameters in horses.Therefore,treatment(104Zimetaand34controlalthough mares older than 20 yearshead of the Equine Centre at the Univer-horsesonZimetashouldbemonitored product) and 137 horses (103 Zimeta andyielded fewer oocytes and blastocysts,sity of Melbournes Veterinary School, forclinicalsignsofcoagulopathy.34 control product) were included in the Caution should be used in horses at risk statisticalanalysisforeffectiveness.At6the percentage of blastocysts per injectedin Australia, has been looking at correla-for hemorrhage. hours post-treatment, the success rate was 74.8% (77/103) of Zimeta treated horses andoocyte (13.7%) was no different to thattions between injury risk and racehorses As a class, NSAIDs may be associated with20.6% (7/34) of control horses. The results gastrointestinal, renal, and hepatic toxicity.in younger mares. In other words, oncestride length, speed, and frequency. Sensitivity to drug-associated adverse eventsof the field study demonstrate that Zimeta administered at 30 mg/kg intravenously wasa vets been successful procuring the ova,Researchers know that repeated ap-varies with the individual patient. Considereffective for the control of pyrexia 6 hours stopping therapy if adverse reactions, suchfollowing treatment administration.donor mare age doesnt impact fertiliza- plication of high loads to bones and re-asprolongedinappetenceorabnormal feces, could be attributed to gastrointestinalRefer to the Product Insert fortion success. sulting bone fatigue contribute to injury toxicity. Patients at greatest risk for adversecomplete Effectiveness information. events are those that are dehydrated, onStorage Information: Store at Controlled diuretictherapy,orthosewithexistingRoom Temperature 20 and 25C (68 and renal,cardiovascular,and/orhepatic77F); with excursions permitted between 15Intracytoplasmic dysfunction.Concurrentadministrationofand 30C (59 and 86F). Protect from light.potentiallynephrotoxicdrugsshouldbeMulti-dosevial.Usewithin30daysof sperm injection is carefullyapproachedoravoided.Sincefirst puncture. a form of in vitro manyNSAIDspossessthepotentialto produce gastrointestinal ulcerations and/orHow Supplied: Zimeta is availablefertilization where gastrointestinal perforation, concomitant useas a 500mg/mL solution in a 100mL,a single sperm is of Zimeta with other anti-inflammatory drugs,multi-dose vial.such as NSAIDs or corticosteroids, should beinjected directly Approved by FDA under NADA # avoided. The influence of concomitant drugs141-513 NDC 86078-245-01 into an egg.that may inhibit the metabolism of Zimeta has not been evaluated. Drug compatibilityManufactured for:should be monitored in patients requiringKindred Biosciences, Inc.adjunctive therapy.1555 Bayshore Hwy, Suite 200,The safe use of Zimeta in horses less thanBurlingame, CA 94010 three years of age, horses used for breeding,To report adverse reactions call or in pregnant or lactating mares has not beenKindred Biosciences, Inc. atevaluated.Considerappropriatewashout1-888-608-2542.times when switching from one NSAID toZimeta is a trademark ofKindred COURTESY DR. TOM STOUTanother NSAID or a corticosteroid. Biosciences, Inc.AdverseReactions:Adversereactions 2019 Kindred Biosciences, Inc. All rights reported in a controlled field study of 138reserved.horses of various breeds, ranging in ageRev. 11-2019from 1 to 32 years of age, treated withKB50002_ZIV-BS-1 Zimeta (n=107) or control product (n=31) are summarized in Table 1. The control product was a vehicle control (solution minus 36March 2020The Horse|TheHorse.comAAEPWrapUp.indd 36 2/5/20 2:54 PM'