Parasites: Roads to Resistance

It shouldn’t really surprise us: parasites are becoming increasingly resistant to the drugs we use. Bacteria are now increasingly resistant to antibiotics, malaria parasites are widely resistant to antimalarials, and parasites are no different. We should all learn the lesson from history.

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Historical approaches to deworming have fueled parasite resistance to anthelmintics.

It shouldn't really surprise us: parasites are becoming increasingly resistant to the drugs we use. Parasites simply follow Darwin's law: survival of the fittest. In fact, all biological organisms have this ability to adapt to the environment through evolution. As a result, bacteria are now increasingly resistant to antibiotics, malaria parasites are widely resistant to antimalarials, and insects are now vastly resistant to a number of insecticides. Parasites are no different, and we should all learn the lesson from history.

For 40 years we've treated parasites very intensely, and the results are clear: horses are still exposed to the same species as 40 years ago, and the only major difference is that our drugs are losing their effect. This is worrisome since it remains unknown whether or not new drugs will be introduced to the market, and, if so, when

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Martin Krarup Nielsen, DVM, PhD, Dipl. ACVM, is an associate professor of parasitology and the Schlaikjer professor in equine infectious disease at the University of Kentucky’s Maxwell H. Gluck Equine Research Center, in Lexington. His research focus includes parasite diagnostic measures and drug resistance. Known as a foremost expert in the field of equine parasites, Nielsen chaired the American Association of Equine Practitioners’ (AAEP) parasite control task force, which produced the “AAEP Parasite Control Guidelines.”

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