Cushing’s Disease

Information on pituitary pars intermedia dysfunction (PPID), also known as Cushing’s Disease in horses.

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Cushing’s Horses Sought for Pergolide Study

Elanco Animal Health (a division of Eli Lilly and Company), in collaboration with Michigan State University, Oklahoma State University, and Louisiana State University, is seeking horses with equine Cushing’s disease, also known as pituitary pars

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Carb Testing Program for Horse Feed and Hay

When it comes to horses, what does “low carb” mean? Lower than what? “There are several analytical procedures that measure sugar, and each one measures a slightly different fraction,” said Kathryn Watts, BS, owner of Rocky Mountain Research & Consult

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Healthy Horses: Endocrine System Function and Flaws

Horses suffer from few endocrine disorders compared to humans and companion animals; however, they’re not totally off the hook, explained Emily Graves, VMD, MS, Dipl. ACVIM, of Michigan State University, to horse owners in attendance at the

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What Causes Pituitary Pars Intermedia Dysfunction?

The lack of dopamine is critical, as the activity of the pars intermedia is normally inhibited (controlled) by dopamine. Without dopamine, the pars intermedia produces much more hormone than it should, causing the clinical signs of PPID.

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Diagnosing Pituitary Pars Intermedia Dysfunction

Unfortunately, no perfect PPID test (one that is 100% accurate with a single-sample test) yet exists. At the 2006 AAEP Convention, Harold Schott, DVM, PhD, Dipl. ACVIM, professor of large animal clinical sciences at Michigan State University,

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Challenges of Cushing’s Disease Diagnosis and Treatment

We know Cushing’s disease (or pituitary pars intermedia dysfunction?PPID?as it’s more scientifically called), simply put, is an “old-horse disease” that results in metabolism disturbances and an abnormally heavy hair coat. But when it comes to

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Pergolide: FDA to Allow Compounding From Bulk


The Food and Drug Administration’s (FDA) Center for Veterinary Medicine announced on May 11 it will allow bulk pergolide to be used in compounding pergolide for use in horses.

Pergolide mesylate, a drug commonly used to treat pituitar

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