Using Artificial Intelligence to Predict Fragile Foal Syndrome

Researchers used AI to analyze horse conformation and detected differences between fragile foal syndrome carriers and noncarriers that might have performance implications.

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newborn foal
Horses with fragile foal syndrome often do not live long after birth. | Photo: iStock
Fragile foal syndrome (FFS) is a genetic variant in horses that leads to defects in the connective tissues, including very thin skin, a deformed spine, open body cavities, and sores on the body in homozygous (meaning they have two copies of it) animals and can be fatal. Veterinarians and breeders originally discovered the condition in Warmblood horses and in recent years have reported increases in its frequency, said Hadley Rahael, of the Brooks Equine Genetics Lab at the University of Florida, in Gainesville, during her presentation at the 2023 Equine Science Society Symposium, held June 6-9 in Grapevine, Texas. Therefore, equine researchers recently sought to learn what might be driving this increasing frequency and how the FFS variant impacts the biomechanics of the equine athlete, she added.

Conformation is important for soundness, athletic ability, and ultimately the intended use of the horse,” said Rahael. “Horses are generally selected for breeding based on performance traits, which might mean that we are inadvertently breeding more horses that are carriers of the gene, if the carrier state has some performance benefit.”

To perform the study the researchers used artificial intelligence (AI) technology to observe the horses’ conformation and genotyped them to determine whether they were carriers of the FSS variant. They enrolled 35 privately owned sport horses (10 mares and 25 geldings) in the study, with three noncarrier control horses for every carrier (determined through genotyping at the beginning of the study).

To collect their conformation data for the AI system, the researchers jogged each horse on a designated path perpendicular to the camera. They investigated the following parameters for association with the FFS variant:

  • Head length.
  • Neck length.
  • Right forelimb length (from elbow to knee and knee to fetlock).
  • Right hind-limb length (from stifle to hock and hock to fetlock).

The researchers analyzed three frames per horse in the same stride stage at the trot and scaled the measurements by head length. “We found that the carriers of FFS had longer neck and hind-limb lengths than those that were noncarriers,” said Rahael.

“In future studies, we will continue to increase the sample size as well as use more than just the limb and neck length for analysis.”

This study confirmed AI’s ability to help quantify aspects of sport horse conformation and detected differences between fragile foal syndrome carriers and noncarriers that might have performance implications. This new technology is a positive starting point for future research on this topic, she added.


Written by:

Haylie Kerstetter, Digital Editor, holds a degree in equine studies with a concentration in communications and a minor in social media marketing. She is a Pennsylvania native and, as a horse owner herself, has a passion for helping owners provide the best care for their horses. When she is not writing or in the barn, she is spending time with her dog, Clementine.

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