Over the past century, improvements in health care and advancements in biology, chemistry, and medicine have extended the average lifespan of humans and companion animals, including horses. However, we are now facing new challenges with the paradox of an older population with increased longevity, while confronted with the potential for many years of poor health. A better understanding of the mechanisms leading to a decline in physiologic function with age would provide new predictive biomarkers and potential therapeutic targets.

It has been well-documented that the aged, including horses, have increased susceptibility to and prolonged recovery from infectious diseases, poor responses to vaccination, and increased incidence of various cancers. Furthermore, it is now accepted that chronic inflammation (inflamm-aging) is a major underlying condition of many age related diseases, such as arthrosclerosis, arthritis, cancer, diabetes, osteoporosis, dementia, vascular diseases, obesity, and metabolic syndrome.

ONarutal Dietary Compounds with Anti-Inflammatory Mechanisms

Group Compound
Carotenoids Beta-carotene, lycopene, lutein
Flavonoids Quercetin, catechin, epigallocatechin-3-O-gallate, theaflavin
Isothiocyanates Sulforaphane, phenethyl, isothiocyanate
Terpenoids Limonene, retinoic acid
Omega-3 fatty acids Eicosapentaenoic acid, docosahexaenoic acid
Polyphenolic compounds Curcumin, gingerol, resveratrol, pterostilbene

In anti-aging research, much attention is focused on nutritional interventions as practical, cost-effectiv