Researchers Validate New Equine Drug-Testing Method
“By employing high-resolution mass spectrometry in the full-scan mode, we can detect, theoretically, an unlimited number of targeted drugs in a single run, provided that all these drug targets can be ionized and detected in the instrument,” said Terence S.M. Wan, PhD, EurChem, CSci, CChem, FRSC, FAORC, FCSFS, head of the racing laboratory and chief racing chemist at The Hong Kong Jockey Club. “That means new drug targets can easily be incorporated into these methods as well.”
The “dilute-and-shoot” method already exists in human doping control, but it hasn’t been adopted as a widespread method in equine testing, Wan said. Many current methods in equine testing require an intermediate step of substance extraction from the sample. This step is not only time-consuming, but it’s also “quite ineffective” for very polar (waterlike) or zwitterionic (neutral molecules having both positive and negative charges) substances because it’s hard to extract them from water-based biological fluids.
With “dilute-and-shoot,” however, there’s just a simple dilution step before injecting the sample directly into the analytical instrument. “This requires minimal effort in sample preparation, which makes it quick and easy,” Wan
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