Study: Aspirin Ineffective as a Blood Thinner in Some Horses

A recent study has revealed that aspirin’s effects on horses seem less pronounced than in humans. In fact, some horses might be resistant to it.
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Study: Aspirin Ineffective as a Blood Thinner in Some Horses
This could have significant implications in cases in which veterinarians prescribe aspirin to treat diseases with increased platelet activation, such as endotoxemia or laminitis. | Photo: iStock
Veterinarians prescribing aspirin to thin horses’ blood might want to reconsider their decision. A recent study has revealed that aspirin’s effects on horses seem less pronounced than in humans. In fact, some horses might be resistant to it.

“Based on my data and that of others in previous published studies, there is probably less anticoagulatory efficacy of aspirin in horses,” said Katja Roscher, DrMedVet, Dipl. ECEIM, of the Justus Liebig University Department of Veterinary Clinical Science Equine Clinic, in Giessen, Germany.

In their study, Roscher and her fellow researchers tested how a five-day aspirin treatment affected coagulation (blood clotting) properties in 10 horses. They gave the horses a loading dose (4.7-5 mg/kg) orally the first morning and a maintenance dose (1-1.3 mg/kg) every day for the following four days.

Seven horses initially showed a marked reduction in platelet aggregation (clotting), ranging from a 37% to 100% reduction only six to 12 hours after the loading dose, Roscher said. But over the next four days, the researchers saw much less reduction, with a lot of variation from horse to horse, ranging from 0% to

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Passionate about horses and science from the time she was riding her first Shetland Pony in Texas, Christa Lesté-Lasserre writes about scientific research that contributes to a better understanding of all equids. After undergrad studies in science, journalism, and literature, she received a master’s degree in creative writing. Now based in France, she aims to present the most fascinating aspect of equine science: the story it creates. Follow Lesté-Lasserre on Twitter @christalestelas.

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