Bute vs. Firocoxib: Which NSAID Results in More Severe Gastric Ulcers?

Both NSAIDs induced GI tract inflammation, but phenylbutazone might result in more severe inflammation in the lower GI tract.
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Bute vs. Firocoxib: Which NSAID Results in More Severe Gastric Ulcers?
Non-steroidal anti-inflammatory drugs (NSAIDs) are the second-most frequently used drug class in horses after dewormers. | Photo: iStock

Non-steroidal anti-inflammatory drugs (NSAIDs) are the second-most frequently used drug class in horses after dewormers. Veterinarians prescribe them for a wide range of issues ranging from post-surgical recovery to orthopedic issues. While they’re invaluable for managing horses’ pain, one of their side effects is gastric ulcers.

A group of researchers from Texas A&M University recently compared two types of NSAIDs’ effects on gastric ulceration in horses. Lauren M. Richardson, DVM, a resident in large animal surgery at the College of Veterinary Medicine and Biomedical Sciences, presented their findings at the 2017 American Association of Equine Practitioners convention, held Nov. 17-21 in San Antonio, Texas.

But first, let’s review how NSAIDs work

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Clair Thunes, PhD, is an equine nutritionist who owns Clarity Equine Nutrition, based in Gilbert, Arizona. She works as a consultant with owners/trainers and veterinarians across the United States and globally to take the guesswork out of feeding horses and provides services to select companies. As a nutritionist she works with all equids, from WEG competitors to Miniature donkeys and everything in between. Born in England, she earned her undergraduate degree at Edinburgh University, in Scotland, and her master’s and doctorate in nutrition at the University of California, Davis. Growing up, she competed in a wide array of disciplines and was an active member of the U.K. Pony Club. Today, she serves as the district commissioner for the Salt River Pony Club.

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