Autologous Conditioned Serum Composition Evaluated
Joint disease: It’s progressive, incurable, and widely prevalent among performance horses. Veterinarians can, however, provide affected horses with some relief in the form of conventional therapies, such as corticosteroids and/or hyaluronic acid injections or, in severe cases, biologic therapy. One such treatment is autologous conditioned serum (ACS), also called IRAP (interleukin-1 receptor antagonist protein).
At the 2015 American Association of Equine Practitioner’s convention, held Dec. 5-9 in Las Vegas, Dane Tatarniuk, DVM, MS, clinical instructor in equine surgery and sports medicine at the University of Minnesota’s College of Veterinary Medicine, in St. Paul, presented a study in which he and colleagues examined the composition of ACS—in particular an anti-inflammatory cytokine called the interleukin-1 receptor antagonist , or IL-1ra.
“There is prior evidence of this biologic therapy helping; however, the entire composition of ACS is unknown,” he explained. “Prior research has focused predominately on IL-1ra, however many proteins (both anti-inflammatory and pro-inflammatory) may be present within the therapy.”
But first, a little background on how ACS works. When a joint sustains injury, trauma stimulates the release of inflammatory proteins within the joint including IL-1 and other cytokines (proteins that signal cells to move toward inflammation sites). These accelerate and worsen inflammation, contributing to cartilage degradation that leads to an overall downward spiral of joint
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