Can DNA Testing Lead to Better Endometritis Treatments?

Researchers found that particular genetic types of E. coli responded to the various antibiotics differently.
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Endometritis, an inflammation of the endometrium (the inner lining of the uterus), is one of the leading reasons for poor pregnancy rates in mares. It has several causes, including infectious organisms and a mare’s inability to clear debris from her uterus after breedeing.

Bacterial endometritis associated with Escherichia coli can be particularly challenging to treat due to the bacteria’s ability to adapt in the face of treatment and the wide range of antimicrobial resistance (ranging from highly susceptible to highly resistant) observed. Jennifer Morrissey, DVM, a resident at Colorado State University’s Equine Reproduction Laboratory in Fort Collins, decided to see if she could differentiate between types of E. coli based on genetic grouping and correlate these differences with antibiotic resistance and biofilm formation.

She presented the results of her preliminary study at the 2016 Theriogenology Conference, held July 27-30 in Asheville, North Carolina.

Escherichia coli is one of the most common bacteria isolated from the equine uterus, representing 30-50% of all cases of infectious endometritis,” Morrissey said

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Alexandra Beckstett, a native of Houston, Texas, is a lifelong horse owner who has shown successfully on the national hunter/jumper circuit and dabbled in hunter breeding. After graduating from Duke University, she joined Blood-Horse Publications as assistant editor of its book division, Eclipse Press, before joining The Horse. She was the managing editor of The Horse for nearly 14 years and is now editorial director of EquiManagement and My New Horse, sister publications of The Horse.

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