How Does Long-Term NSAID Use Affect the Horse’s Gut Microbiome? 

Dr. Robert Jacobs describes the potential effects of long-term NSAID use on the horse’s gut microbiome.

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medication bottle, NSAID
Photo: The Horse Staff

Non-steroidal anti-inflammatory drugs (NSAIDs) are an important part of many horses’ soundness management programs. But what effects do they have on a horse’s gut? Dr. Robert Jacobs of Purina explains how long-term NSAID use might affect your horse’s gut microbiome and what you can do to combat these effects. 

This podcast is an excerpt of our Ask TheHorse Live Q&A, “Maintaining the Equine Gut Microbiome.” Listen to the full recording here.

About the Expert

Robert Jacobs

Dr. Robert Jacobs

Robert Jacobs, MS, PhD, is the Equine Innovation Manager at Purina Animal Nutrition. Jacobs and his team conduct innovative research focused on nutrition for horses, including palatability and eating behavior, gastrointestinal physiology, microbiome studies, exercise physiology, and growth and development. They perform their studies at the equine unit of the Purina Animal Nutrition Center in Gray Summit, Missouri, a 300-acre facility home to more than 80 horses ranging in age from newborn to 30. Jacobs earned his BS and MS in Animal Sciences from the University of Florida and continued his studies, completing his PhD in equine reproductive physiology and nutrition at Virginia Polytechnic Institute and State University, where he investigated the role of omega-3 supplementation on the equine uterine environment and early pregnancy in obese, metabolically compromised horses. Research is a passion for Jacobs, but his favorite part of the day includes walking the pastures to check on the horses.


Written by:

Haylie Kerstetter, Digital Editor, holds a degree in equine studies with a concentration in communications and a minor in social media marketing. She is a Pennsylvania native and, as a horse owner herself, has a passion for helping owners provide the best care for their horses. When she is not writing or in the barn, she is spending time with her dog, Clementine.

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