COX-2 Expression in Equine Tumors (ACVIM 2006)

Therapies for equine cancer are few and far between, but a veterinary oncologist from Colorado State University (CSU) thinks equine tumors could be treated with non-steroidal anti-inflammatory drugs (NSAIDs).
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Therapies for equine cancer are few and far between, but a veterinary oncologist from Colorado State University (CSU) thinks equine tumors could be treated with non-steroidal anti-inflammatory drugs (NSAIDs). Doug Thamm, VMD, Dipl. ACVIM, an assistant professor in oncology at CSU’s College of Veterinary Medicine & Biomedical Sciences, presented research at the American College of Veterinary Internal Medicine’s Forum on June 1 in Louisville, Ky. He described how some tumors he examined expressed the enzyme cyclooxygenase-2 (COX-2). COX-2-inhibiting NSAIDs could be appropriate for treating these growths.

COX-2 is an enzyme that stimulates the production of prostaglandin E2, a protein that might stimulate growth and establishment of a tumor while helping the tumor evade the immune system. "The pharmacologic inhibition of COX-2 with NSAIDs has been associated with antitumor activity in various human and canine malignancies, including canine oral squamous cell carcinoma (SCC)," said Thamm.

He and his colleagues examined 14 sarcoids and 39 SCC, and they found that COX-2 was expressed in two of 14 sarcoids (14%) and 35 of 39 SCC (90%). Sarcoids are generally considered less harmful than SCC.

"Based on this information, a majority of equine SCC appear to express COX-2 and thus might be responsive to treatment with NSAIDs," Thamm said, noting that further study of NSAID therapy for equine tumors is warranted

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Stephanie L. Church, Editorial Director, grew up riding and caring for her family’s horses in Central Virginia and received a B.A. in journalism and equestrian studies from Averett University. She joined The Horse in 1999 and has led the editorial team since 2010. A 4-H and Pony Club graduate, she enjoys dressage, eventing, and trail riding with her former graded-stakes-winning Thoroughbred gelding, It Happened Again (“Happy”). Stephanie and Happy are based in Lexington, Kentucky.

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